The role of angiotensin Ⅱ and its receptor in the pathogenesis of diabetic cardiomyopathy
- VernacularTitle:血管紧张素Ⅱ及其受体在大鼠糖尿病性心肌病发生中的作用
- Author:
Guohong WANG
;
Shenyuan YUAN
;
Yantao BIAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, experimental;
Myocardial disease;
Angiotensin Ⅱ;
Receptor
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of local angiotensin Ⅱ (ATⅡ) and its receptor (ATR) in the pathogenesis of diabetic cardiomyopathy. Methods Wistar rats were divided into two groups: 3 month group included control and streptozotocin (STZ) induced diabetic rats and 6 month group included control, diabetic rats, and Losartan treated diabetic rats (3 mg?kg -1 ?d -1 orally from 3rd to 6th month after diabetes was induced). The cardiac function, ATⅡ and ATⅡ receptor were determined. Results The left ventricular diastolic dysfunction appeared in diabetes in 3rd month 〔-dp/dt max : (687?86 vs 864?94)mm Hg/s, P
