Comparative study of PDGF－B and BMP－7 receptors distribution on histiocytes of interface membranes around aseptic loosened prostheses
- VernacularTitle:无菌性松动假体周围界膜组织中PDGF-B和BMP-7受体的分布及其临床意义
- Author:
Xu CAI
;
Jifang WANG
;
Shibi LU
- Publication Type:Journal Article
- Keywords:
Joint prosthesis;
Bones;
Metabolism;
Receptors,platelet－derived growth factor;
Bone morphogenetic proteins
- From:
Chinese Journal of Orthopaedics
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the orientation of tissue differentiation at bone implant interface by comparing PDGF－? and BMP－ 7 receptor distribution on histiocytes of interface membranes around aseptic loosened prosthesis. Methods Interface membrane tissues of osteolysis and non- osteolysis regions around aseptic loosened prostheses of 10 cases were immunohistochemically stained by PDGFR－? and ActR－Ⅰ (ALK－ 2) multiclonal antibodies. The relative grey values of 100 positive cells of each factors from every case were determined by computerized image analysis system and were compared between different groups and cells. Results No specificity of PDGFR－? distribution on different kinds of cells of interface membrane. PDGFR－? expression on macrophages and fibroblasts of the membranes at osteolysis regions was significantly higher than that at non- osteolysis regions (P
