Effect of tamoxifen on germ cells and its clinical application in idiopathic oligospermia
- VernacularTitle:它莫昔芬对原因不明少精子症生精细胞增殖与凋亡的影响
- Author:
Yaxuan WANG
;
Guangzeng CAI
;
Wenqing CAI
- Publication Type:Journal Article
- Keywords:
Infertility,male;
Azoospermia
- From:
Chinese Journal of Urology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of tamoxifen on the proliferation and apoptosis of germ cells and to evaluate its clinical application to idiopathic oligospermia. Methods 41 oligospermia patients were treated with tamoxifen.Testicular tissues obtained by Tur Cut biopsy needle,both before and after the treatment,were observed under electron microscopy,the incidence of apoptosis and PCNA expression in germ cells being detected. Results Testicular pathological changes in different degree were observed on electron microscopy.Compared with the normal controls.PCNA proliferation index (PI) was lower ( P
