Influnence of 17-? estradiol and progesterone on synthesis of transforming growth factor beta-1 in hyperplastic scar fibroblasts
- VernacularTitle:17-?雌二醇、孕酮对增生性瘢痕成纤维细胞转化生长因子-?_1合成的影响
- Author:
Yujia WU
;
Kaihua LU
;
Linxi ZHANG
- Publication Type:Journal Article
- Keywords:
Hypertrophic scar;
Fibroblasts;
Transforming growth factor;
Estrogen;
Progetin
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influnence of estrogen and progestin on scar formation. Methods By culturing hyperplastic scar fibroblast(HSFB), we investigated TGF ? 1 synthesis by immunohistochemical staining and image analysis. Results The detectable level of TGF ? 1 in HSFB treated with 17 ? E 2 was higher than that of the control significantly( P 0.05). Conclusion In vitro, 17 ? E 2 can stimulate TGF ? 1 synthesis in HSFB significantly.
