The effects of ovariectomy and cholesterol rich diet on the content of estrogen receptor in vascular endothelial cells and hearts of female rats
- VernacularTitle:卵巢切除及高脂饮食对雌鼠心脏组织、血管内皮细胞雌激素受体含量的影响
- Author:
Saizhu WU
;
Jianguo LIU
;
Yunjun RUAN
- Publication Type:Journal Article
- Keywords:
Ovariectomy;
Endothelium cells vascular;
Receptors estrogen
- From:
Chinese Journal of Geriatrics
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ovariectomy and cholesterol rich diet on the change of estrogen receptor content of vascular endothelial cells and hearts of female rats. Methods The receptor binding assay (RBA) was adopted to measure the content of estrogen receptors, and the serum levels of estradiol and lipids were measured. Results The content of ER was much lower in hearts and VEC of ovariectomy〔(0.51?0.09) fmol/mg pro,(6.73 ? 0.52) fmol/106 cell〕and cholesterol rich rats〔(0.97?0.12) fmol/mg pro,(9.15 ?0.53) fmol/106 cell〕than pseudo-operation rats 〔(2.08?0.15) fmol/mg pro ,(17.66?1.26) fmol/106 cell , P
