The protective effects of nicotine from MPTP-induced Parkinson's disease in C57BL mice
- VernacularTitle:烟碱对帕金森病小鼠保护效应的研究
- Author:
Tao CHEN
;
Beisha TANG
;
Yinghua PANG
- Publication Type:Journal Article
- Keywords:
Nicotine;
Morphine derivatives;
Parkinson disease
- From:
Chinese Journal of Geriatrics
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of nicotine on the metabolism of dopamine (DA) in the striatum and on the spontaneous locomotor activity of MPTP-induced PD mice. Methods 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model in mice was prepared. The effects of MPTP and nicotine on the levels of dopamine, its metabolites of 3,4-dihydroxyphenlacetic acid (DOPAC) and hemovanillic acid (HVA) were analyzed with high-performance liquid chromatography and electrochemical detection(HPLC-EC); also, tyrosine hydroxylase (TH)-positive nerve fibers were measured by immunohistochemical analysis. Results After injection of Nicotine, the spontaneous locomotor activity of MPTP-treated C57BL mice was significantly lower than that of the control mice, suggesting the nicotine's inhibiting effects ( 44.86?8.51 vs. 57.28?3.27, P
