Two Cases of Reversible Neutropenia Associated with Olanzapine-Valproate Combination Treatment.
- Author:
Shi Hyun KANG
1
;
Jung Keun OH
;
Jong Il LEE
;
An Kee CHANG
Author Information
1. Department of Psychiatry, Seoul National Hospital, Seoul, Korea. drshe@hanmail.net
- Publication Type:Case Report
- Keywords:
Neutropenia;
Olanzapine;
Valproate;
Combination therapy
- MeSH:
Agranulocytosis;
Antipsychotic Agents;
Benzodiazepines;
Humans;
Leukopenia;
Neutropenia;
Valproic Acid
- From:Journal of Korean Neuropsychiatric Association
2010;49(6):653-656
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The novel antipsychotic, olanzapine, has structural and pharmacological properties similar to clozaine. Antipsychotic drugs, as well as mood stabilizers, can cause neutropenia, which can progress to life-threatening agranulocytosis if the medication is not discontinued. We report two cases of reversible neutropenia associated with a olanzapine-valproate combination treatment. This report suggests that patients treated with the combination of olanzapine and valproate should be monitored for the occurrence of leukopenia and neutropenia.
