Amyloid-? protein deposition in area of axon degeneration in Goll’s column of mouse
- VernacularTitle:薄束轴索变性小鼠轴索内淀粉样?蛋白蓄积的研究
- Author:
Jiang WU
;
Kangding LIU
;
Mingli RAO
- Publication Type:Journal Article
- Keywords:
Amyloid beta protein;
Mouse;
Nerve degeneration;
Spheroids;
Medulla oblongata
- From:
Chinese Journal of Neurology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between axon degeneration of Goll’s column system and Amyloid ? protein (A?) deposit sludge. Methods A? protein deposition in area of axon degeneration of Goll’s columns was measured by using immunohistochemical method.Results There was found strong positive round like A? deposit in the area of axon degeneration of Goll’s column system of GAD mouse. Spheroid appeared in the area of medullar nucleus of the Goll's column system at an age of 4 weeks. However the A? was negative and 9 weeks later, it became positive in partial spheroid and formed a strong round like material and became more and more standing up with age increase. The material mentioned above appeared consistently progressive in degeneration of axon in sequence.Conclusion It was suggested that the deposition of A? should be the result secondary to degeneration of nervous axon and be closely correlated with axon degeneration.
