Antituberculosis drug-induced hepatotoxicity (ATDH): Report of 11 cases
- Author:
Phan Vuong Khac Thai
- Publication Type:Journal Article
- Keywords:
Hepatotoxicity
- MeSH:
Toxicity;
liver;
Tuberculosis;
Pharmaceutical Preparations
- From:Ho Chi Minh city Medical Association
2004;4(5):275-278
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Antituberculosis drug-induced hepatotoxicity (ATDH) is common during treatment of tuberculosis. The incidence of PZA-induced hepatotoxicity was substantially higher than that of first line anti-TB drugs. In this study, 11 patients with evidence of antituberculosis drug-induced hepatotoxicity were study. ATDH developed within the first 2 months of the treatment (intensive phase). The common symptoms were fatigue (100%), nausea, vomiting (36%), jaundice (18%). The median transaminase index was 5 for both ALT, AST. Potential of risk factors are age of the patient > 35 (45%), alcoholism (45%), hepatitis B C virus carrier status (27%). Futher studies with large numbers of enrolled patients and control subjects are needed to be conducted in the future
