Ifosfamide and other 3 drugs chemotherapy for 24 cases with recurrent intermediate—high grade non-Hodgkin's lymphoma
- VernacularTitle:异环磷酰胺等4种药物联合治疗24例复发性非霍奇金淋巴瘤
- Author:
Chen XU
- Publication Type:Journal Article
- Keywords:
lymphoma;
chemotherapy;
ifosfamide;
mitoxantrone;
pingymycin;
prednisone
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the salvage treatment of recurrent intermediate—high grade non Hodgkin lymphoma(NHL). Methods:24 cases of recurrent intermediate—high NHL were divided into two groups: 10 cases with poor prognostic factors in group one(G1), 14 cases without poor prognostic factors in group two(G2).All cases were treated with ifosfamide(IFO), mitoxantrone(Mx), pingyangmycine(PYM), prednisone(Pred) (IMPP). IFO 1.5 g/m 2 iv on days 1 to 4, and mesna iv at hours;0, 4, 8 Mx 8 mg/m 2 on day 1; PYM 5mg/m 2 im on days 8 and 15; and Pred 100mg/d po on days 1 to 5. Every 4 weeks as one cycle. Assessment was given after 2 cycles. Results:The total CR rate was 58.3%(14/24), RR 79.2%(19/24). The CR rate was 30%(3/10), RR 60%(6/10) in G1 and the CR rate was 78.5% (11/14), RR 92.8%(13/14) in G2 ,respeetively. The difference of the two groups in CR and RR was significant( P
