A study of the mechanism of the effect of a recombinant vaccinia virus expressing human cartcinoembryonic antigen on CEA positive tumor
- VernacularTitle:CEA重组痘苗病毒免疫治疗CEA阳性肿瘤机制的研究
- Author:
Qing ZHAO
;
Sha TAO
;
Jie YANG
- Publication Type:Journal Article
- Keywords:
Carcinoembryonic antigen Recombinant vaccinia virus Adoptive immunotherapy CEA positive tumor
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore antitumor mechanism of a recombinant vaccinia virus expressing human carcinomembryonic antigen(rV CEA).Methods:C57bl/6 mice were immunized three times with rV CEA.Six weeks later,the splenocytes from rV CEA immunized donors were adoptively tranfered in sublethally irradiated CEA + HePa bearing recipients,meanwhile the antiumor effect of the donor splencytes in virtro was detected.Results:Splenocytes from rV CEA immunized donors expressed strong antiumor activity in CEA positive tumorbearing recipients,whereas W VV immunized and nonimmune donor cell did not.The antiumor activity was abolished when immune T cells were depleted before splencytes transfer.Conclusion:It was demonstrated that antiumor acivity induced by rV CEA was essentially mediated by immune T cells which were activated by CEA specific immune response.Adoptive immunotherapy strategies may have implications for both the study of rV CEA and the development of potential clinical applications for tumor immunotherapy.
