Flunarizine used as an open add-on therapy in an increasing dosage for the treatment of intractable partial epilepsy seizure
- VernacularTitle:氟桂利嗪剂量递增法治疗难治性癫痫部分性发作的疗效观察
- Author:
Renfei MA
;
Benxiu ZHOU
;
Yi YANG
- Publication Type:Journal Article
- Keywords:
Flunarizine;
Epilepsy, partial;
Seizures
- From:
Chinese Journal of Neurology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy and safety of flunarizine (FNR) used as an open add on therapy with increasing dosage for treatment of intractable partial seizures (IPS) Methods Fourty three patients with IPS received FNR add on therapy more than 6 months in addition to the medication of existing antiepileptic drug The administration of FNR in increasing dosage was executed as follows: for children aged 8 12 years,the initial dosage was 5 mg/d in the first week,then with a subsquent increase of 5 mg/d every week; for adult,10 mg/d for the first week,and then increased 10 mg/d each week And at the fourth week,the dosage of FNR for children was added up to 20 mg/d,and for the adult, 40 mg/d served as a maintenance dosage continuously for 6 months Results Two patients dropped out for personal reasons Three cases discontinued FNR add on therapy because of untolerable adverse effects of increasing dosage Thiry eight patients accomplished the whole course of 6 month treatment Total effective rate was 63%,in which there was 75% for simple partial seizures (SPS), 62% for complex partial seizures(CPS) and 56% for the secondary general seizures(SGS) There was a seizure reduction of 69% as compared with pre FNR treatment period ( P
