Effects of vitamin D_3 and vitamin K_3 on experimental urolithiasis in rats
- VernacularTitle:维生素D_3和维生素K_3对实验性肾结石的影响
- Author:
Liansheng CHANG
;
Tao FENG
;
Juxiang LI
- Publication Type:Journal Article
- Keywords:
Kidney calculi;
Vitamin D 3;
Vitamin K 3;
Animals,laboratory
- From:
Chinese Journal of Urology
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between urolithiasis and vitamin D 3 as well as vitamin K 3. Methods 36 adult male SD rats were randomized to control group、stone forming group、vitamin D 3 group、vitamin D 3+stone forming group、vitamin K 3 group and vitamin K+stone forming group.OPN and its mRNA of kidneys were detected,and the crystal components in urine were determined. Results Vitamin D 3 and vitamin K 3 could enhance the expression of OPN mRNA in rat kidneys of stone models.Vitamin D 3 could increase the concentration of calcium in urine significantly.Vitamin K 3 could inhibit the excretion of oxalate in urine and also inhibits the deposition of oxalate crystals in kidney. Conclusions The results indicated that vitamin D 3 may promote stone formation via various mechanisms,whereas vitamin K 3 could inhibit this process.
