Study of the antiapoptosis mechanism of clusterin in EJ bladder carcinoma cell line.
- VernacularTitle:Clusterin对膀胱癌细胞抗凋亡作用机制的研究
- Author:
Lili LIANG
;
Qiang ZHANG
;
Chung LEE
- Publication Type:Journal Article
- Keywords:
Clusterin;
ladder neoplasm;
Carcinoma;
Apopto
- From:
Chinese Journal of Urology
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of novel antiapoptosis factor clusterin in EJ cell. Methods MMC was used to induce apoptosis of EJ cells and the ratio of apoptosis was studied by flowcytometry after the use of clusterin. Results Clusterin in low dose can inhibit the apoptosis induced by MMC. Conclusions Clusterin can influence the development of bladder cancer by antiapoptosis.The expression of clusterin may have some relationship with the drug resistance or recurrence of bladder cancer.The study of clusterin is helpful to elucidate the biological mechanism of the bladder cancer and direct the therapy of bladder cancer using the antibody of clusterin.
