Effect of HELICOBACTER PYLORI infection on apoptosis and proliferation along with P53 gene expression in gastric epithelium
- VernacularTitle:幽门螺杆菌感染对胃粘膜上皮细胞凋亡和增殖及P53基因表达的影响
- Author:
Zhong ZHANG
;
Yuan YUAN
;
Hua GAO
- Publication Type:Journal Article
- Keywords:
HELICOBACTER PYLORI;
gaastric precancerous lesions;
apoptosis;
proliferation;
P53 gene
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the relationship between HELICOBACTER PYLORI (Hp) and gastric carcinoma, as well as the possible carcinogenic mechanism by Hp. Methods: DNEL technique and immunohistochemical staining were used in the research to study the state of apoptosis, proliferation and p53 gene expression. Total 100 gastric mucosal biopsy specimens, including normal mucosa, Hp negative and Hp positive gastric precancerous lesions as well as gastric carcinomas were studied. Results:There were several apoptotic cells in the superficial epithelium and a few proliferative cells within neck of gastric glands, and no p53 protein expression in normal mucosa. In gastric carcinoma, apoptotic cells accounted for 1.62%, while proliferative cells 4.99%, and P53 protein significantly increased. in metaplasia, the apoptotic index (AI), proliferative index (PI) and positivity of p53 expression in Hp positive group were higher than those in normal mucosa ( P
