The effect of the polymorphism of (AC)_n in the 5'-end of the aldose reductase gene on the erythrocyte aldose reductase activity in the patients with type 2 diabetes mellitus
- VernacularTitle:醛糖还原酶基因5’端(AC)_n多态性对2型糖尿病患者红细胞醛糖还原酶活性的影响
- Author:
Xiaoman ZOU
;
Juming LU
;
Changyu PAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, non insulin dependent;
Aldose reductase;
Gene;
Polymorphism
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of the polymorphism of (AC) n of aldose reductase (AR) gene on the erythrocyte AR activity in type 2 diabetes mellitus (DM). Methods One hundred and sixty three cases of type 2 DM and forty two controls were included in this study. The subjects were devided into DM without diabetic microangiopathy (DMAP) (NDC) (66 cases), DMAP groups (97 cases), and normal controls (CON) (42 cases); further, according to the type of allele, the subjects were devided into DM with Z+2 (DZ+2) (54 cases), DM with Z-2 (DZ-2) (35 cases), DM with both Z+2 and Z-2 (Z+2/Z-2) (18 cases), DM with neither Z+2 nor Z-2 (X/X) (56 cases), non DM with Z+2 (NZ+2) group (21 cases) and non DM with Z-2 (NZ-2) groups (7 cases). AR activity (ARA) was measured by modified Sriratava method. The differences of ARA were compared among these groups. Results ARA in DMAP group was significantly higher than that in NDC group, ARA in NDC group was significantly higher than that in CON group. Among DZ-2, DZ+2, Z+2/Z-2 and X/X groups, ARA was the highest in DZ-2 group and the lowest in DZ+2 group. ARAs in DZ-2 and NZ-2 groups were significantly higher than those in DZ+2 and NZ+2 groups respectively. In DZ-2 and DZ+2 groups ARA was significantly higher than that in NZ-2 and NZ+2 groups respectively. Conclusion The activation of AR plays an important role in the development of DMAP. Z-2 allele may be an activator and Z+2 allele may be an inhititor of AR.
