The application of reduced sample number of Bergman's minimal model method in insulin resistance syndrome
- VernacularTitle:减少样本数的Bergman最小模型技术在胰岛素抵抗综合征中的应用
- Author:
Jie HONG
;
Guang NING
;
Xiaowei WANG
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Diabetes mellitus, non insulin dependent;
Glucose intolerance;
Obesity;
Glucose tolerance test
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of insulin resistance in obesity, impaired glucose tolerance (IGT) and type 2 diabetes. Methods Insulin sensitivity index (SI), glucose effectiveness (S G) and insulin secretory function of ? islet cells were assessed by the reduced sample number of Bergman's minimal model method with frequently sampled intravenous glucose tolerance test in patients with obesity, IGT and type 2 diabetes as well as in the controls. Body mass index (BMI) and waist hip ratio (WHR) were determined in four groups. Results SI and S G were significantly higher in the controls than those in the IGT and type 2 diabetes patients. The S G in obesity group was nearly the same as that in the controls, but its SI was significantly lower. The area under curve 1 (AUC 1) of insulin in the controls was smaller than that in obesity and IGT (P
