Titin antibody in myasthenia gravis and its clinical significance
- VernacularTitle:重症肌无力患者血清连接素抗体的检测及其临床意义
- Author:
Xiangjun CHEN
;
Jian QIAO
;
Chuanzhen LB
- Publication Type:Journal Article
- Keywords:
Myasthenia gravis;
Autoantibodies;
Thymom
- From:
Chinese Journal of Neurology
1999;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of titin antibody(titinab) in myasthenia gravis(MG) Methods Recombinant MGT-30 peptide was synthesized by genetic engineering technique We had examined titinab in the sera of 141 MG patients with different thymic pathology(MG group),265 normal controls(NC group) and 36 diseased controls without MG(NMG group) using recombinant MGT-30 as antigen of ELISA Acetylcholine receptor antibody(AChRab) and presynaptic membrane receptor antibody(PrsmRab) were parallelly examined in MG patients Results The titer of titinab in the sera of MG patients was significantly higher than those of NC group and NMG group( P
