The relationship between the effect of carbamazepine on chromosome aberration rate and sister chromatid exchange frequencies and the folic acid in epileptic patients
- VernacularTitle:卡马西平对癫痫患者染色体畸变率和姐妹染色单体交换频率的影响及与叶酸的关系
- Author:
Shuyu LI
;
Bingqing LB
;
Zhaohui CHEN
- Publication Type:Journal Article
- Keywords:
Carbamazepine;
Epilepsy;
Chromosome aberrations;
Sister chromatid exchange;
Folic acid
- From:
Chinese Journal of Neurology
1999;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the mutagenicity of carbamazepine (CBZ) and folic acid (FA), and to explore the mechanism of CBZ teratogensis and the prevention effect of the folic acid. Methods Peripheral blood lymphocyte chromosome aberration rate (CAR), sister chromatid exchange (SCE)frequencies, and serum FA levels have been studied in 15 CBZ -treated epileptic patients, 15 CBZ plus FA-treated epileptic patients The untreated epileptic patients and the health subjects were served as controls Results CAR and SCE frequencies were significantly higher in CBZ group as compared with the CBZ plus FA group and the controls ( P
