The effects of recombinant human growth hormone on cancellous bone of ovariectomized rats
- VernacularTitle:重组人生长激素对卵巢切除大鼠松质骨的影响
- Author:
Suizhu HUANG
;
Kerong DAI
;
Liben JIANG
- Publication Type:Journal Article
- Keywords:
Somatotropins, recombinant;
Osteoporosis, postmenopausal;
Bone density;
Histology;
Animal testing alternatives;
Rats, Sprague-Dawl
- From:
Chinese Journal of Orthopaedics
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of recombinant human growth hormone on cancellous bone of ovariectomized rats with remarkable bone loss. Methods Six-month old Sprague-Dawley(SD) rats were used to receive low, middle and high doses of recombinant human growth hormone three months after ovariectomy. Bone mineral density and bone histomorphormetry were used to study the alteration of cancellous bone of lumbar vertebrae. Results Recombinant human growth hormone significantly increased bone mineral density and improved the cancellous bone volume and trabecular bone architectures. Conclusion Recombinant human growth hormone can restore the bone loss in ovariectomized rats and improve the trabecular bone architectures. However, its effect is dose related.
