RELATIONSHIP BETWEEN TELOMERASE ACTIVITY AND THE BIOLOGICAL BEHAVIOR OF PROSTATE CANCER
- VernacularTitle:前列腺癌生物学行为与端粒酶活性表达的相关性研究
- Author:
Xu SONG
;
Jian ZHOU
;
Peng TANG
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Telomerase;
Immunoenzyme techniques
- From:
Cancer Research and Clinic
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between telomerase activity and the biological behavior of prostate cancer.Methods:The telomerase activity in prostate cancer tissues was detected by TRAP (telomeric repeat amplification protocol) ELISA which is based upon amplification of the initial telomerase product and detected by ELISA.Results:None of the 10 samples from normal prostates expressed telomerase activity.The thirteen of fifteen cases (86.0%) with prostate cancer presented telomerase activity.The activity of telomerase was associated with the pathological differentiation of prostate cancer.The two of twelve cases (17.0%) with benign prostatic hyperplasia (BPH) expressed telomerase activity,and the activity of telomerase was lower than prostate cancer.Conclusion:The telomerase acitivity may be related to the biological behavior of prostate cancer and can evaluate the malignant potential of prostate cancer.The presence of telomerase acitivity in some cases of BPH may indicate the presence of a minority of malignant cells,as yet clinically undetected,within the population of BPH cells.
