CLINICAL STUDY OF MDR1 AND MRP GENE EXPRESSION IN PATIENTS WITH GASTRIC CARDIA CANCER
- VernacularTitle:贲门癌组织中多药耐药基因和多药耐药相关蛋白基因表达的临床研究
- Author:
Yanming WANG
;
Aimin WANG
;
Jie CHEN
- Publication Type:Journal Article
- Keywords:
Gastric cardia cancer;
MDE1 and MRP gene expression;
RT-DCR
- From:
Cancer Research and Clinic
1999;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of MDR1 gene expression inpatients with gastric cardia carcinoma.Methods Using reverse transcription-polymerase chain reaction(RT PCR), the genes expression of MDR1 and MRP, in 4 6 cases of gastric cardia cancer was determined.Results Positive expression of MDR1 and MRP gene were 6:3% and 50% respectively, which was muchhigher than that in tissue adjacent to 1ilo cancer site. In 9 cases of pre-operative chemotherapy , the levels ofMDR 1, and MRP gene expression were higher higher that without chemotherapy (P
