Regulation of MMP-2 and Cath-D by Interferons in Human Osteosarcoma Cell Line OS-732
- VernacularTitle:干扰素对骨肉瘤细胞MMP-2和Cath-D表达的调节作用
- Author:
Cuang WU
;
Fengxun GAO
;
Dong WANG
- Publication Type:Journal Article
- Keywords:
Osteosarcoma;
Metalloproteinases;
Cathepsins;
Interferons
- From:
Chinese Journal of Orthopaedics
1999;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the regulatory effects of IFNs on the expression of MMP - 2 andCath - D in osteosarcoma cell and provide experimental evidence for clinical treatment of osteosarcomametastasis. Methods The changes of MMP - 2 and Cath-D were half quantatively measured by Cell ELISA in a human osteosarcoma cell line OS - 732, treated with IFN - ? and IFN -?. Results The resultdemonstrated that both of IFNs were capable of significantly decreasing their expression (P
