bcr_3/abl_2 ANTISENSE OLIGODEOXYNUCLEOTIDE INDUCES APOPTOSIS IN CHRONIC MYELOID LEUKEMIA
- VernacularTitle:bcr_3/abl_2反义寡核苷酸诱导慢性髓细胞白血病凋亡作用的研究
- Author:
Zhenchuan SHANG
;
Bingzhong SUN
;
Xiaoping XIE
- Publication Type:Journal Article
- Keywords:
Leukemia. myeloid. chronic Oncogene Apoptosis Antisense oligodeoxynucleotide
- From:China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
PURPOSE To investigate the effects of bcr3/abl2 anisense oligodeoxynucleotide (ASO) on chronic myeloid leukemia (CML). METHODS The effects of bcr3/abl2 ASO in 15 CML patients were evaluated by morphological observation, flow cytometer (FCM) techniques and DNA fragment measurement. RESULTS bcr3/abl2 ASO can induce apoptosis in CML. CONCLUSION Antisense techniques may provide a new way to cure CML.
