COMBINED CHEMOTHERAPY OF LATE MALIGNANT TUMORS WITH HIGH-DOSE CALCIUM LEUCO-VORIN (CF) AND 5-FLUOROURACIL (5-FU)
- VernacularTitle:高剂量甲酰四氢叶酸钙与氟尿嘧啶联合化疗治疗晚期恶性肿瘤
- Author:
Qinhe TAN
- Publication Type:Journal Article
- Keywords:
Calcium leucovorin 5-Fluorouracil Combined chemotherapy Malignant tumors
- From:China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
PURPOSE To observe the curative effects obtained from combined chemotherapy of late malignant tumors with high-dose CF and 5-FU used as amain drug. METHODS Twenty-one patients with late cancer were divided into two groups: the one with 15 cases of cancer in the digestive tract and the one with 6 cases of mammary cancer. The patients with cancer of the alimentary canal were treated with CF and 5-FU combined with DDP and MMC while those with mammary cancer were treated with CF and 5-FU combined with CTX and ADM. RESULTS The effective rate was 40. 0 percent for cancer of the digestive canal and 66. 6 percent for mammary cancer. Toxic actions and side effects were mainly local phlebitis, nausea, vomiting and leukopenia. CONCLUSION The use of routine 5-FU chemotherapy in alimentary-canal cancer and mammary cancer will improve curative effects if CF is added for biochemical regulation.
