COMPARATIVE STUDY OF p~(53) GENE TRANSCRIPTS IN THYROID TUMOR AND ADJA-CENT TISSUES OF THYROID TUMOR
- VernacularTitle:甲状腺肿瘤及瘤旁组织p~(53)基因表达的对比
- Author:
Gebo WEN
;
Renxin CAO
- Publication Type:Journal Article
- Keywords:
Tumor,thyroid p53 Gene Gene expression
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To determine whether p53 gene transcripts were altered in thyroid tumor and adjacent tissues of thyroid tumor, total RNA from 12 tumor specimens (9 carcinomas and 3 adenomas) and 4 adjacent tissues of thyroid tumor was exmined by Northern blot hybridization and reverse transcription——polymerase chain reaction. It was found that p53 gene transcripts were present in all tumors and the adjacent tissues of tumor and were significantly more obvious in the samples of carcinomas as compared with those of adenomas and in the samples of tumor as compared with those of the adjacent tissues of tumor. These data suggest that excessive p53 gene expressions are involved in thyroid carcinogenesis.
