RELATIONSHIP BETWEEN ERYTHROCYTE SORBITOL AND DIABETIC MICROAN-GIOPATHY IN PATIENTS WITH NIDDM
- VernacularTitle:NIDDM患者红细胞山梨醇与糖尿病微血管病变的关系
- Author:
Bo ZHOU
;
Shuping WANG
;
Jinglin YANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus , non-insulin-dependent Sorbitol Microangiopathy,diabetic
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To explore the relationship between the activity of polyol pathway and diabetic microangiopathy, the level of red blood cell sorbitol(RBCS)in 106 patients with NIDDMwas determined. The results indicated that the level of RBCS in diabetic patients was significantly increased, and was positively correlated with 24-h urinary albumin excretion rate(UAER)and the degree of diabetic retinopathy(DR). Besides,the value of RBCS in patients with both pro-teinuris and DR or proteinuria was markedly higher as compared with that in patients with either proteinuria or DR,and the concentration of RBCS in the patients with DR of proteinuria was also significantly higher than those wth neither proteinuria nor DR. In addition.it was also found that the value of RBCS gradually elevated with the aggravation of UAERand DR. These findings suggest that the elevation of RBCS level plays an important role in the formation and development of diabetic microangiopathy.
