MECHANISM OF PROTECTION AFFORDED BY TESTOSTERONE TO THE PANCREATIC ISLET CELLS INJURED BY INTERLEUKIN-1?
- VernacularTitle:睾酮对白介素-1?损伤的胰岛细胞的保护机制
- Author:
Haili FANG
;
Ling WANG
;
Yingkui YANG
- Publication Type:Journal Article
- Keywords:
Interleukin-1? Testosterone Insulin
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Isolated pancreatic islet cells from neonatal rats were cultured in vitro. Insulin release was significantly inhibited by interleukin-1?. Addition of testosterone to the IL-, 1?-impaired pancreatic islets could increase insulin release, suggesting a protective effect of testosterone on pancreatic islet cells. Testosterone also significantly increased the insulin content in islet cells, and this effect could be blocked by actinomycin-D, indicating that testosterone promoted the synthesis of DNA and insulin may be one of its major protective mechanism.
