EFFECT OF HYPERTHYROIDISM ON DEVELOPMENT OF ENCEPHALIC CHOLINER GIC NEURONS DURING THE CRITICAL STAGE OF BRAIN DEVELOPMENT IN RATS
- VernacularTitle:大鼠脑发育临界期内甲亢和甲减对中枢胆碱能神经元发育的影响
- Author:
Zhaoying LI
;
Ruifeng YANG
;
Zupei CHEN
- Publication Type:Journal Article
- Keywords:
Hypothyroidism Hyperthyroidism Brain development Ace-tyfransferase Acetylcholinesterase
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The choline acetyltransferase (CHAT) and the molecular forms of acetyl-cholinesterase (ACHE) activites in various brain regions of 20-day-old hypothyroid and hyper-thyroid rats were measured. The results provided the following information: 1) CHAT and ACHE activities were directly interrelated with thyroid hormones. 2) In both hypothyroid and hyperthyroid rats the nonextractable ACHE activity was distinctly decreased in every brain region, suggesting that both conditions were affected in the critical period of cholinergic synaptic development. 3) The ratio of membrane-bound ACHE to soluble ACHE decreased;it showed that thyroid hormone deficiency might distrub development and maturation of cholinergic neurons. 4) In most regions of the central nervous system,the CHAT seemed to be more affected than ACHE by thyroid hormones.
