EVALUATION OF RENIN-ANGIOTENSIN SYSTEM IN DIAGNOSIS AND TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA——AN ANALYSIS OF 22 CASES
- VernacularTitle:肾素系统检测在先天性肾上腺皮质增生症中的诊治价值——22例临床分析
- Author:
Jun YE
;
Xiaodong HUANG
;
Yongnian SHEN
- Publication Type:Journal Article
- Keywords:
Adrenal hyperplasia, congenital Renin-angiotensin system
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Eleven salt-losers (SL group) and eleven non-salt-losers (NSL group) of congenital a-drenal hyperplasia due to 21-hydroxylase deficiency (21-OHD) were evaluated for sodium status under routine regimen of glucocorticoid (4 salt-losers with mineralocorticoid at the same time). Venous samples were collected for the measurement of plasma renin activity (PRA), aldosterone (Aldo) , and a-drenocorticotropin (ACTH), and for serum cortisol (F), 17-OH progesterone (17-OHP), and testosterone (T). Urine samples were collected for 17-ketosteroid (17-KS). 10 age-matched normal children were chosen as control. The results showed that concentration of PRA, Aldo, 17-OHP, and T, were higher in both groups than in normal subjects (P
