EXPRESSION OF T_3 RECEPTOR c-erbA? mRNA IN EXPERIMENTAL HYPERTHYROID AND HYPOTHYROID RATS
- VernacularTitle:实验性甲状腺功能亢进和减退大鼠的T_3受体?亚型mRNA表达
- Author:
Yuzhen LIU
;
Yan GAO
;
Tienhao CAI
- Publication Type:Journal Article
- Keywords:
T3receptor mRNA,c-erbA?
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The rat c-erbA? cDNA fragment was used as probe to investigate the expression of T3 receptor gene in brain, heart and kidney in hyperthyroid and hypothyroid rats. There were three types of c-erbA? mRNA-6. 0kb, -5. 0kb and -2. 0kb in all examined tissues. In heart and kidney, the levels of c-erbA? mRNA decreased in hyperthyroid rats and increased in hypothyroid rats. It might be a compensatory mechanism. In brain, however, the level of c-erbA? mRNA was unaffected by thyroid status. The results suggest that the T3 receptor gene may have an auto-regulatory mechanism in rat heart and kidney under different thyroid status.
