INTRATHYROIDAL MACROPHAGE INFILTRATION AND T CELL ACTIVATION IN AUTOIMMUNE THYROID DISEASE
- VernacularTitle:自身免疫性甲状腺疾病巨噬细胞浸润与T细胞活化
- Author:
Jian WANG
;
Zhulan WANG
;
Genbao FENG
- Publication Type:Journal Article
- Keywords:
Thyroid disease,autoimmune Macrophage T cell activation Immunocytochemistry
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In thirty seven patients with autoimmune thyroid disease (AITD) intrathyroidal macrophages (M ) and activated T cells were identified by alkaline phosphatase anti-alkaline phosphatase (APAAP) immunocytochemical technique using monoclonal antibodies Ki-M8, TLiSA 1 and anti-Tac. Different degrees of infiltration of M (Ki-M8-) and activation of T cells (TLiSA1- or Tac-) were seen in the thyroid tissue of Hashimoto thyroiditis (HT), Graves disease (GD) and Graves disease with thyroiditis(GDAT). However, there were no significant difference in proportions of the positive staining reactions among the different diseases. Staining of serial sections revealed a significant correlation between the proportions of Me and activated T cells in thyroid gland mononuclear cells (TG-MNC). It suggests that infiltration of M may have an influence on intrathyroidal T cell activation in AITD.
