CHANGE IN NUMBER AND DISTRIBUTION OF PANCREATIC A- AND B-CELLS IN DIABETIC CHINESE HAMSTER
- VernacularTitle:中国地鼠糖尿病模型胰岛A、B细胞数量及分布改变
- Author:
Qiuhe JI
;
Huici SU
;
Shaowen HU
- Publication Type:Journal Article
- Keywords:
Hamster,Chinese Diabetes model, experimental Cytology, islet
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The change in pancreatic A- and B-cells in Chinese hamsters with spontaneous hereditary diabetes mellitus were investigated with specific immunohistochemical and image analyzing methods. A variety of pathological changes of the islets and change in number and distribution of the pancreatic A- and B-cells were found in diabetic Chinese hamsters. Microscopic examination revealed that the intensity of staining reaction of pancreatic B-cells varied greatly and the number of A-cells increased in this model. The results of image analysis showed that the range of the average optical density of B-cell staining was 54.4% wider than that in the control and the percentage of the glucagon positive immunoreactive area in the islet was significantly higher in diabetic Chinese hamsters(31.6?13.2%)than in the controls(21. 8?7.5%). These findings suggest that the islet cytology of this diabetic model changes significantly.
