An experimental study on adrenal glands homotransplantation to the subrenal capsule in adult rats
- VernacularTitle:成龄大鼠肾上腺同种异体肾被膜下种植的实验研究
- Author:
Guitang LI
;
Jianguang GAO
;
Yanzong MIAO
- Publication Type:Journal Article
- Keywords:
Rats Adrenl glands Transplantation, homllogous
- From:
Chinese Journal of Urology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
adult female Wistar rats undergone bilateral adrenelectomy were diveded to four groups:(A)simple bilateral adrenalectomy;(B)bilateral adrenalectomy with pieces of adrenal glands alloimplanted to the subrenal capsule (SRC);(C)the same with group B followed by institution of cyclosporing A(CsA) from the operative day to the 14th postoperative day;(D) group C plus ACTH given from 3rd to 31st postoperative day. Five months follow-up showed that all the grafts survived, regenerated and the serum corticosteron levels were in correspondence with histological features. This result showed SRC is an ideal site for adreal homotransplantation. Varying degrees of lymphocytyc infiltration were present in the implants in group B on the 2nd to 21st postoperative day, the fragment in groun C and D in which CsA was given did not show any lymphocytic infiltration, even after CsA was discussed. ACTH instituted in group D remarkably enhances the regenerative speed of the grafts After CsA and ACTH were stopped, no rejection episode appeared and the adrenal grafts survived well. The result has been similar to clinical homotransplantation of adrenal glands with vasculas anastomosis.The technigue is simple and the adrenal gland used for homotransplantation is easy to obtain.
