The effects of oxymatine on Lymphocytes' second messengers
- VernacularTitle:氧化苦参碱对淋巴细胞第二信使的影响
- Author:
Huixian WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
We studied the effects of oxymatine,an alkaloid from Sophra Flavesens Ait,on human andmouse's lymphocytes' cytoplasmic free calcium,calium uptaking,cAMP & cGMP level.Theresults show that:(1).Oxymatrine can raise the cytoplasmic free calcium.(2).It can also de-crease the cAMP level of PHA preactivated human tonsillar lymphocytes (3).It has no effect oncGMP level of lymphocyte.(4).It has no effect on the calcium uptaking.Combined with ourprevious report,we think that oxymatrine may influence cells' [Ca++] and cAMP level via af-fecting cell membrane.
