Improved effect of Gwe on mutagenesis in mice induced by X—ray & IL—1
- VernacularTitle:Gwe改善X射线诱变生成与IL—1
- Author:
Xiuying LU
- Publication Type:Journal Article
- Keywords:
Gwe;
Chromosome aberration;
Micronucleus;
Sister-chromatid exchange;
IL-1
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Gwe is a new immunological response modifier extracted from traditional Chinese herbs.Inour experiments,We demonstracted that:1.Gwe could significantly inhibite micronucleus fre-quencies in mouse bone marrow cell and decrease both the chromosome aberration (CA) and Sis-ter— chromatid exchang frequencies of splenocytes in mice induced by 1.5Gy X—ray.2.itcould up—regulate the level of IL—1 like substance of splenocytes in mice induced by X—ray.3.there was negetive correlation between the level of IL—1 like substance in the cultured spleencell supernatant and micronucleus frequencies in bone marrow cells or CA frequencies in spleencells.
