STUDY ON THE ENZYMATIC CHEMISTRY IN CANTHARIDIN POISONED RATS (Ⅱ)——THE CYTOCHEMISTRY OBSERVATION OF NADHD AND CCO
- VernacularTitle:斑蝥素中毒大鼠酶化学研究(Ⅱ)——NADHD及CCO的细胞化学观察
- Author:
Zhenshan LIU
;
Mingjun LIU
;
Weixing LU
- Publication Type:Journal Article
- Keywords:
cantharidin;
nicotinamide adenine dinucleotide dehydrogenase (NADHD);
cytochrome oxidase (CCO);
cytochemistry
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Based on the histochemical observation ofnicotinamide adenine dinucleotide dehydrogenase(NADHD) and eytochrome oxidase (CCO) activi-ties of myocardium in cantharidine poisoned rats,furthermore, we observed the changes of these en-zymes of the myocardium cytochemically. The re-sult showed that, compared with control group, NADHD and CCO activities were inhibited afteradministration of cantharidin 1 or 2 h, and the in-hibition was found to be more obvious with poison-ing times prolonged, after 24 h, the cristae of mi-tochondria can not be distinguished, and the reac-tion products diffued into stroma to become a ho-mogeneous mass and lost their normal localization.It is indicated that cantharidin might destroy thestructure of mitochondria and interfere the activi-ties of NADHD and CCO of which both are locatedon mitochondria.
