THYROGLOBULIN ANTIBODY PRODUCTION BY CULTURED PERIPHERAL BLOOD MONONUCLEAR CELLS FROM PATIENTS WITH AUTOIMMUNE THYROID DISEASE
- VernacularTitle:自身免疫甲状腺病单个核细胞体外培养产生抗甲状腺球蛋白抗体
- Author:
Yi YANG
- Publication Type:Journal Article
- Keywords:
Autoimmune thyroid disease Peripheral blood mononuclear cell Thyroglobulin antibody
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Thyroglobulin antibody (TGA) production in vitro by cultured peripheral blood mononuclear cells (PBMC) from patients with autoimmune thyroid disease (AITD) was measured by ELISA technique. PBMC from patients with AITD could synthesize and secret detectable amount of TGA. The average positive rate of TGA production in vitro was 31.25%. PBMC from the patients with Hashimoto thyroiditis (HT) could produce TGA more easily than that from the patients with Graves'disease (GD). The average positive rate was 44.19% in HT and 16.22% in GD. Pokeweed mitogen could increase TGA production, but soluable thyroglobulin could not stimulate TGA synthesis and secretion. Antithyroid drug methi-mazole had some inhibition effect on TGA production in vitro. A significant positive correlation between the serum TGA and the amount of TGA produced in vitro by PBMC from HT patients (r = 0.4, P
