THE PRIMARY RESEARCH ON THE EVALUATION OF THE CARDIAC RESERVE FUNCTION BY RESTING LEFT VENTRICULAR PERFORMANCES IN RATS WITH ADRIAMYCIN CARDIOMYOPATHY
- VernacularTitle:大鼠阿霉素心肌病静息心脏功能评价心泵贮备功能的初步探讨
- Author:
Lijun LIU
;
Jisheng YANG
;
Xing LU
- Publication Type:Journal Article
- Keywords:
cardiac reserve function;
resting left ventricular performance;
adriamycin cardiomyopa-
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To find out the method of assessing the car-diac reserve function under the resting condition,we observed the changes of left ventricular con-tractility, relaxation and compliance, as well ascardiac pump function under the resting and over-loaded conditions with intact hearts of male rats invarious states of heart failure induced by variousadriamycin cumulative doses. The results of thepresent study indicated that the degree of my-ocardium injury was aggravated along with the in-crease of adriamycin cumulative doses. Mean-while, all of the parameters of left ventricular con-tractility, relaxation, compliance and cardiac re-serve function decreased significantly. However,the indexes of basic cardiac pump function in-creased to a certain extent because of the influenceof non-cardiac factors. The discriminant analysisshowed that the degree of heart failure assessed bymeans of the discriminant function, or synthesizingthe changes of left ventricular contractility, relax-ation and compliance under the resting condition,was almost consistent with that by means of thecardiac reserve function. In addition, the multipleregression indicated that the contractility, relax-ation and compliance had different effects on thecardiac reserve function, corresponding to the different states of heart failure.
