THE STUDY OF T-CELL SUBSETS AND IL-2 LEVEL IN PATIENTS WITH MULTIPLE MYELOMA
- VernacularTitle:多发性骨髓瘤患者T细胞亚群及白细胞介素-2水平变化的研究
- Author:
Xianliang ZHOU
;
Wenbin SHAO
;
Jingtian ZHANG
- Publication Type:Journal Article
- Keywords:
multiple myeloma;
T-cell subsets;
interleukin-2 (IL-2)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to determine the cellular immunestate in patients with multiple myeloma, T-cellsubsets in peripheral blood from 25 cases withmultiple myeloma were measured with SPA-Ig di-rect rosette assay, the activity of interleukin-2 wasinvestigated by using mice thymocyte proliferationassay. The results showed that in multiple myelo-ma, OKT_3~+, OKT_4~+ cell decreased significantly.OKT_6~+ cell increased markedly and the OKT_4/OKT_8 ratio was reduced. The activity of IL-2 in pe-ripheral blood lymphocytes of the patients withmultiple myeloma increased sharply and there wasa significant difference between the active diseaseand the remission disease. The activity of IL-2 inthe remission disease was lower than that in theactive disease but higer than that of the controlgroup. In conclusion, this study indicated thatthere were imbalance of T-cell subsets and abnor-mality of IL-2 production in patients with multiplemyeloma. The data might suggest that there wasdisorder of the cellular immunity in the course ofthe disease.
