Immunoregulatory effect of 1,25-dihydroxyvitamin D_3 on human peripheral blood lymphocytes
- VernacularTitle:1,25二羟维生素 D_3对人淋巴细胞免疫功能的调节作用
- Author:
Weitong MU
- Publication Type:Journal Article
- Keywords:
1,25-dihydroxyvitamin D_3;
mixed lymphocytes reaction;
interleukin-2 receptor;
transferrin receptor
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of 1,25-dihydroxyvitamin D_3 on PHA-and alloantigen-induced human peripher-al blood lymphocyte proliferation,expressions of IL-2R and TfR were investigated by ~3H-TdRincorporation and indirect immunofluorescence methods respectively,The results demonstratedthat 1,25— (OH)_2D_3 had an inhibitory effect on PHA-induced proliferation (IC_(50)=19.1nM),which could partially reversed by exogenous recombinant IL-2,1,25 (OH)_3D_3 at high doses(10-100nM) it had an inhibitory effect.In both PHA-stimulated and alloactivated lymphocytes1,25(OH)_2D_3 could inhibit the expression of TfR and had no effect on that of IL-2R.This studysuggests that 1,25 (OH)_2D_3 in an important immunoregulatory hormone,the properties of whichneed further clarification.
