Vaccines against Coccidioides.
10.3904/kjim.2013.28.4.403
- Author:
Hee Jung YOON
1
;
Karl V CLEMONS
Author Information
1. Division of Infectious Diseases, Department of Internal Medicine, Eulji University Hospital, Daejeon, Korea. yhj822@medimail.co.kr
- Publication Type:Review
- Keywords:
Fungal vaccines;
Coccidioidomycosis
- MeSH:
Animals;
Coccidioides/*immunology/pathogenicity;
Coccidioidomycosis/immunology/microbiology/*prevention & control;
Fungal Vaccines/*therapeutic use;
Humans;
Virulence
- From:The Korean Journal of Internal Medicine
2013;28(4):403-407
- CountryRepublic of Korea
- Language:English
-
Abstract:
Vaccines against fungal diseases are gaining attention because of their growing impact on modern medicine. Development of these vaccines should incorporate immunological tools that integrate with or replace chemotherapy to minimize antibiotic use and consequent resistance. In this review, we evaluate the current developmental status of fungal vaccines against coccidioidomycosis. There is a need for a vaccine that sufficiently prevents disease, without eradicating the fungus, by neutralizing adhesions and enzymes or other low penetrance virulence traits.
