Contrasuppressive activity of the T cell Subsets with vicia lectin receptor in systemic lupus erythematosus
- VernacularTitle:人体T细胞CD_8~+VV~+亚群在活动性SLE患者中显示反抑制活性
- Author:
Dongqing ZHANG
- Publication Type:Journal Article
- Keywords:
Contrasuppressor T cell(TCS);
Vicia villosd lectin receptor(VVR);
Flow cytometry(FCM);
Systemic lupus erythematosus(SLE)
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
Contrasuppressor T cells (TCS) take part in immunoreglation by rendering T help cells re-sistant to the effects of suppressor cells.It was found that both human and mouse TCS expressreceptor for vicia villola letcin (VVR).Human effective TCS are mainly CD8VV~+ T subsetswhich are closely associated with abnormalities of immune activity of many diseases.By usingroutine and double immunofluorescent labelling techniques combined with flow cytometry,dif-ferentVV~+ subsets were analysed.A significant increase was observed for CD8VV~+ cells in ac-tive SLE (23.6%)as compared with the control group (8.5%) and the SLE patients in remis-sion (14.49%).The percentage of CD4VV~+ subset,however,was unchanged.Moreover,thetypical contrasuppressive activities exerted by VV~+ cells,which were also increased significantlyin active SLE patients,were detected in SLE in a dose—dependent manner.In an experimentwith PPD—induced lymphoproliferation as indicating system,for example,the relative respons-es were observed to be increased doses in from 100% to 485% and 625% after the VV~+ cellswere added back in increased doses,suggesting that the contrasuppressive VV~+ or CD8VV~+cells were added back in increased doses,suggesting that the contrasuppressive VV~+ or CD_8VV~+cells Were closely related to the immune disorders of SLE.
