The effect of tuftsin and thymopentin on phagocytic function in mice
- VernacularTitle:促吞噬肽和胸腺五肽对小鼠单核吞噬细胞功能的影响
- Author:
Qinhui XU
;
Pingping YANG
;
Kangtai RONG
- Publication Type:Journal Article
- Keywords:
Tuftsin: Thymopentin;
Phagocytic activating action;
Lysozyme;
Acid phosphatase
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The stimulate effects of synthetical endogenous peptides, tuftsin (Tuf) and thymopentin(TP5), on phagocytic function were studied. After subcutaneous administration (sc) of Tuf, thelysozyme content in both M? and sera, and the acid phosphatase activity in M?, were increasedin a dose-dependent manner. The peak time of serum lysozme level following a sigle sc injectionof Tuf was about on the 6th day. The elevation of lysozyme in sera was delayed and enhancedstrongly by Freund incomplete adjuvant (FIA). In cylcophosphamide (Cy) treated mice,TP5further increased both lysozyme content amd acid phosphatase activity in M?activated byCy, and recovered the lysozyme level in spleen inhibited by cy. The results suggested thatTP5could not only activate the funceion of M?, but recover the number of M?decreased by im-mumoimhibitant.
