Effect of Tumor-derived Immunosuppressive Factor Produced by a HL-60 Cell Line (HL-60) on the Action of T lymphocytes and its Characteristic of Biology
- VernacularTitle:HL-60细胞产生的肿瘤免疫抑制因子对T细胞的作用及其生物学特性
- Author:
Yejin YANG
;
Yongmu HUANGFU
;
Zhaocong CHEN
- Publication Type:Journal Article
- Keywords:
HL-60 human promyelocytic leukemia cell line;
tumor-derived immunosuppressive factor;
interleukin 2
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Immunosuppressive activities have been found in the culture supernatant of four leukemiacell lines and in the sera of four patients with leukemia. The inhibitors suppressed PHA-p in-duced lymphocytes proliferation and IL-2 production and responsiveness of T cells to IL-2, butno inhibitory activity was observed in the culture supernatant of 2BS cell line or in the sera ofnormal humam. The culture supernatant of tumor cell lines was not cytoxic. The result of PAGEshows: the molecular weight of TDSF from HL-60 human promyelocytic leukemia is about87KD. It is protein in chemical nature. The synthesis and sercretion of TDSF were partially in-hibited by drugs of anti-acute non-lymphocytic leukemia.
