THE ALTERATION OF LOCAL AND CIRCULATING RENIN-ANGIOTENSIN SYSTEM(RAS) DURING MECHANICAL-OVERLOAD CARDIAC HYPERTROPHY OF RATS
- VernacularTitle:机械负荷过度性心肌肥大时心脏局部和循环RAS的变化
- Author:
Bin TIAN
;
Guangdao GAO
;
Xing LU
- Publication Type:Journal Article
- Keywords:
cardiac hypertrophy;
angiotensin Ⅰ,Ⅱ;
renin
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
We studied the alteration of local and circulat-ing RAS during cardiac hypertrophy caused by ab-dominal aorta constriction (AC, with nephrectomyof left side) and aorta-vena fistula (AVF). Bothventricular and plasma angiotensin Ⅰ and Ⅱ (AngⅠ. Ⅱ), and plasma, renin actvity (RA) weremeasured by means of radioimmunoassay after twoand seven weeks of surgery. Despite the level ofplasma Ang Ⅰ, Ⅱ and RA were not enhanced, theventricular Ang Ⅰ and Ⅱ were increased signifi-cantly in AC rats (v. s. SO group P
