NEGATIVE INOTROPISM OF THE EFFECT OF FeSO_4 ON ISOLATED GUINEA PIG HEART ATRIUM
- VernacularTitle:硫酸亚铁对豚鼠离体心房肌负性肌力作用
- Author:
Xin MA
;
Li YU
;
Guangwei LUO
- Publication Type:Journal Article
- Keywords:
heart atrium;
FeSO_4;
contractility
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of FeSO_4 upon the physiologicproperties were studied with isolated guinea pig a-trium. The FeSO_4 0. 2mmol/L, makes the contrac-tility of the atrium muscle decrease from 100% ofcontrol to 67 ? 9%. The concentration ofepinephrine inducing automaticity increased andthe duration-intensity curve was shifted to theright. The functional refractory period (FRP) wasprolonged from 298 ? 26 ms to 402 ? 43 ms. Thenegative inotropism and the inhibition of the auto-maticity suggest that FeSO_4 may influence Ca~(2+)movement, while the excitability of suppressionand prolongation of FRP indicate that it may bedue to its inhibition of Na~+ influx.
