The effect of betaendorphin on immune function of rats
- VernacularTitle:?-内啡肽对大鼠免疫功能的影响
- Author:
Xin NI
- Publication Type:Journal Article
- Keywords:
?-endorphin;
lymphocyte proliferation;
interleukin-1;
interleukin-2
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the role of ?-endorphin in the regulation of immune function,we ob-served in vitro and in vivo effects of ?-endorphinon on mitogen--induced spleen lymphocyte pro-liferation,interleukin—1 and interleukin—2 production,It was found that ?-endorphin at 10~(-8)-10~(-14)mol/L could enhance Con A induced proliferation and interleukin-2 production of spleniclymphocyte in vitro.B—endprphin couled also increase LPS induced interleukin—1 productionby peritoneal macropages.The augmentative effect of ?-endorphin on lymphocyte proliferationand interleukin—2 production was abrogate by naloxone.Intravenous injection of ?—endorphinalso increased the lymphoproliferation,interleukin—1 and interleukin—2 production.Our resultsindicated that ?-endorphin enhanced immune function of rats and this action of ?-endorphin maybemediated by opioid receptor.
