PLATELET GSH_(px),SOD ACTIVITIES AND cAMP CONTENTS OF CHILDREN FROM LOW-SELENIUM KESHAN DISEASE AREAS
- VernacularTitle:克山病病区低硒儿童血小板GSH_(px)和SOD活性以及cAMP含量
- Author:
Qifeng YANG
;
Guanglu XU
;
Lianbang ZHAI
- Publication Type:Journal Article
- Keywords:
selenium;
Keshan disease;
superoxide dismutase;
glutathione peroxidase;
platelet;
cyclic adenosine monophosphate
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
In the present study, platelet GSH_(px), SOD activities and cAMP contents, as well as whole blood, erythrocyte, plasma and hair selenium levels were comparatively measured in children from Keshan disease endemic and non-endemic areas. The results showed that blood and hair selenium contents were significantly lower in children of the endemic area than in those of the non-endemic area; children in the endemic area had a signifi cantly lower platelet GSH_(px) activities as compared to those in the non-endemic area, but no remarkable difference of platelet SOD activities and cAMP contents between children in the two areas was observed. The results indicate that the reduced GSH_(px) activity of low-selenium children in the endemic area may result in alterations in platelet functions and arachidonic acid metabolism.
