THE EFFECT OF OXYGEN FREE RADICAL ON DNA ,MATRIX CMPONENT SYNTHESIS AND ULTRASTRUCTUREOF HUMAN EMBRYO CHONDROCYTES
- VernacularTitle:氧自由基对人胚软骨细胞DNA基质成分及超微结构的影响
- Author:
Jie ZHU
;
Xiqin WEI
;
Jian ZHANG
- Publication Type:Journal Article
- Keywords:
cartilage cell;
free radical;
arthritis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
By using the method of chondrocytes in monolayer culture in vitro we observed the effect of free radicals generated by the xanthine oxidase and xanthine on DNA, matrix proteoglycan (PG), collagen synthesis and ultrastructure of human embryo chondrocytes. Our results showed that the synthesis of DNA, PG and collagen of the chondrocytes were obviously inhibited and the membranes and subcellular organelles of the chondrocytes were damaged strongly. On the bases of these results we suggest that oxygen free radicals from poymorphonuclear leukocytes and phagocytes would be the important factors of cartilage injury in arthritis.
